High sperm DNA fragmentation is a common cause of unexplained infertility, repeated IVF failure, and recurrent miscarriage — even when the standard semen analysis appears normal. Testing for DNA fragmentation provides a more complete picture of sperm quality.

When fragmentation is elevated, Dr. Glujovsky will discuss protocol modifications — including the use of testicular sperm (TESA), antioxidant therapy, or embryo selection strategies — that can significantly improve outcomes.

When is DNA fragmentation testing recommended?

• ✓  Couples with unexplained infertility and normal semen analysis
• ✓  Patients with two or more failed IVF cycles
• ✓  Patients with recurrent miscarriage
• ✓  Prior to initiating IVF when male factor is suspected